Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Hyperglycemia-induced oxidative stress in isolated proximal tubules of mouse: the in vitro effects of myricitrin and its solid lipid nanoparticle

(UNSPECIFIED) Hyperglycemia-induced oxidative stress in isolated proximal tubules of mouse: the in vitro effects of myricitrin and its solid lipid nanoparticle. Archives of Physiology and Biochemistry. p. 7. ISSN 1381-3455

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Context: The hyperglycemia (Hyper) induces oxidative stress in kidney tubular cells. Myricitrin (Myr) has an antioxidant effect along with low bioavailability. Objective: The present research investigated the effects of Myr and its solid lipid nanoparticles (SLN) on isolated proximal tubules exposed to the hyperglycemic condition. Materials and Methods: In this experimental study, the proximal tubules of mice were dissected by the microdissection method and the tubules were prepared for experimental or Real Time-PCR measurement. Results: The malondialdehyde level, transforming growth factor-beta, nuclear factor kappa B and Bax genes expression increased in Hyper and decreased in Hyper + Myr and its SLN-treated groups compared to Hyper. Superoxide dismutase, total antioxidant capacity, the viability of proximal tubules and Bcl-2 gene expression decreased in untreated Hyper and increased in all treatment groups compared to Hyper. Conclusion: The hyperglycemia-induced oxidative disorder, inflammation and apoptosis in proximal tubules and that administrating Myr and its SLN improved them.

Item Type: Article
Keywords: Hyperglycemia myricitrin solid lipid nanoparticle proximal tubule mouse high glucose nephropathy apoptosis cells Biochemistry & Molecular Biology Biophysics Endocrinology & Metabolism Physiology
Page Range: p. 7
Journal or Publication Title: Archives of Physiology and Biochemistry
Journal Index: ISI
Identification Number: https://doi.org/10.1080/13813455.2019.1647250
ISSN: 1381-3455
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/9

Actions (login required)

View Item View Item