Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Frequency and genotype distribution of hepatitis C virus infection in patients with diabetes type 2 in Ahvaz, Iran

(2021) Frequency and genotype distribution of hepatitis C virus infection in patients with diabetes type 2 in Ahvaz, Iran. Iranian Journal of Microbiology. pp. 703-711. ISSN 2008-3289

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Abstract

Background and Objectives: Diabetes is recognized as a great concern and a public health problem worldwide. Several factors including environmental and genetic factors have been involved. Recently, infectious agents such as hepatitis C virus (HCV) have been reported to be associated with diabetes. Thus, this study was conducted to determine the frequency of HCV infection among patients with diabetes type 2 in Ahvaz city, Iran. Materials and Methods: A case-control study design was conducted at Ahvaz Jundishapur University of Medical Sciences. A total of 600 study subjects were included in this research. All the patient sera were tested for Anti- HCV antibody, HBsAg, and HIV antibody. The sera of positive Anti-HCV antibody, were assayed for 5'- UTR and core regions of the HCV genome by Nested RT-PCR. Finally, the HCV genotyping was determined by sequencing. Results: The prevalence of HCV in type 2 diabetes and nondiabetic controls was 2 and 0.33, respectively. The distribution of HCV genotypes among the HCV-positive patients were 3a (1.66) and 1a (0.33). Conclusion: To control and improve the treatment, the screening of HCV infection with anti-HCV antibody was followed by molecular techniques such as PCR and HCV genotyping which should be implemented for all patients with diabetes type 2.

Item Type: Article
Keywords: Diabetes mellitus type 2 HCV Prevalence Genotype insulin-resistance mellitus prevalence epidemiology hcv association mechanism health cells 1a Microbiology
Page Range: pp. 703-711
Journal or Publication Title: Iranian Journal of Microbiology
Journal Index: ISI
Volume: 13
Number: 5
ISSN: 2008-3289
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/859

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