Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Parvovirus B19 affects thrombopoietin and IL-11 gene expression in human bone marrow mesenchymal stem cells

(UNSPECIFIED) Parvovirus B19 affects thrombopoietin and IL-11 gene expression in human bone marrow mesenchymal stem cells. Future Virology. p. 8. ISSN 1746-0794

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Official URL: <Go to ISI>://WOS:000678839000001

Abstract

Aim: Human bone marrow mesenchymal stem cells (hBMSCs) may be infected by parvovirus B19 (B19V). hBMSCs support bone marrow hematopoiesis by producing stromal cells, secretion of cytokines and growth factors, etc. Because of the lifetime persistent infection of the virus in healthy individual's bone marrow, this study aims to evaluate B19V effects on hBMSCs gene expression of some crucial hematopoietic cytokines. Materials & methods: hBMSCs were transfected with pHI0 plasmid containing the B19V genome. The quantitative mRNA expression of target genes was evaluated 24 h after transfection. Results: Our findings demonstrated a significant increase in expression levels of IL-11 and TPO (p < 0.05). Conclusion: We concluded that alteration in the gene expressions in B19V-infected hBMSCs might have significant effects on the bone marrow microenvironment as well as hematopoiesis.

Item Type: Article
Keywords: hematopoietic cytokines mesenchymal stem cell parvovirus B19 transfection nonstructural protein stromal cells ns1 protein interleukin-6 infection hematopoiesis promoter pathway target adult Virology
Page Range: p. 8
Journal or Publication Title: Future Virology
Journal Index: ISI
Identification Number: https://doi.org/10.2217/fvl-2021-0020
ISSN: 1746-0794
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/782

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