Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion

(2021) Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion. Scientific reports. p. 660. ISSN 2045-2322 (Electronic) 2045-2322 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/33436672

Abstract

Patients with tuberculous pleural effusion (TPE) or malignant pleural effusions (MPE) frequently have similar pleural fluid profiles. New biomarkers for the differential diagnosis of TPE are required. We determined whether cytokine profiles in the PE of patients could aid the differential diagnosis of TPE. 30 patients with TPE, 30 patients with MPE, 14 patients with empyema (EMP) and 14 patients with parapneumonic effusion (PPE) were enrolled between Dec 2018 and 2019. The levels of interleukin (IL)-6, IL-18, IL-27, CXCL8, CCL-1 and IP-10 were determined in PE by ELISA along with measurements of adenosine deaminase (ADA). The best predictors of TPE were combined ADA.IL-27 optimal cut-off value = 42.68 (10(3) U ng/l(2)), sensitivity 100%, specificity 98.28%, ADA cut off value 27.5 (IU/l), sensitivity 90%, specificity 96.5% and IL-27 cut-off value = 2363 (pg/ml), sensitivity 96.7%, specificity 98.3%, p </= 0.0001. A high level of IL-6 cut-off value = 3260 (pg/ml), sensitivity 100%, specificity 67.2%, CXCL8 cut-off value = 144.5 (pg/ml), sensitivity 93.3%, specificity 58.6%, CCL1 cut-off value = 54 (pg/ml), sensitivity 100%, specificity 70.7% and IP-10 cut-off value = 891.9 (pg/ml), sensitivity 83.3%, specificity 48.3% were also predictive of TPE. High ADA.IL-27, ADA and IL-27 levels differentiate between TPE and non-TPE with improved specificity and diagnostic accuracy and may be useful clinically.

Item Type: Article
Keywords: Potential diagnostic value of pleural fluid cytokines levels for tuberculous pleural effusion.
Subjects: QW Microbiology and Immunology > QW 1-300 Microbiology
WC Communicable Diseases > WC 195-425 Infection. Bacterial Infections
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Microbiology
Page Range: p. 660
Journal or Publication Title: Scientific reports
Journal Index: Pubmed
Volume: 11
Number: 1
Identification Number: https://doi.org/10.1038/s41598-020-79685-1
ISSN: 2045-2322 (Electronic) 2045-2322 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/762

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