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Repository of Research and Investigative Information

Dezful University of Medical Sciences

Althaea officinalis improves wound healing in rats: a stereological study

(2020) Althaea officinalis improves wound healing in rats: a stereological study. Drug Discoveries and Therapeutics. pp. 239-242. ISSN 1881-7831

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Abstract

Althaea officinalis (AO) is reported to have the ability to activate fibroblasts as well as anti-inflammatory and antioxidative properties. Herein, we investigated the effects of this herbal medicine on wound healing in rat models by using stereological methods. In this experiment, 48 male Wistar rats were divided into four groups randomly (n = 12): the control group with no treatment, the gel-base treated group, 5 and 10 AO-gel treated groups. The treatments were administered every 24 hours. Wound closure rate, volume densities of collagen bundles, hair follicles, and vessels, vessel's length density and mean diameter, and fibroblast populations were estimated. Fibroblast populations, hair follicles, and mean diameter of vessels in the dermis of AO-treated groups were noticeably higher than those of control and base groups. Also, collagen bundles synthesis was significantly higher in the AO10-treated group compared to the control and base groups. According to our research and previous studies, AO has the potential to be considered as an alternative medicine in wound healing treatment; however, further clinical investigations are suggested.

Item Type: Article
Keywords: Althaea officinalis wound healing stereology rat antioxidant Pharmacology & Pharmacy
Subjects: QS Human Anatomy > QS504-532 Histology
QY Clinical Laboratory Pathology > QY 50-60 Laboratory Animals
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 239-242
Journal or Publication Title: Drug Discoveries and Therapeutics
Journal Index: ISI
Volume: 14
Number: 5
Identification Number: https://doi.org/10.5582/ddt.2020.03056
ISSN: 1881-7831
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/702

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