Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Effects of maternal immune system status on neonate⇔s immune system

(2020) Effects of maternal immune system status on neonate⇔s immune system. Iranian Journal of Neonatology. pp. 31-37. ISSN 22517510 (ISSN)

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Abstract

Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system. Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate’s humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study. Results: The spleen’s mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P≤0.05) in the anti-sheep red blood cells antibody titer. Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate’s immune responses, spleen, liver, and thymus development. © 2020 Mashhad University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Immune response Maternal Neonate Rat
Subjects: QS Human Anatomy > QS504-532 Histology
QS Human Anatomy > QS604-681 Embryology
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 300-380 Immunologic and Collagen Diseases. Hypersensitivity
WP Gynecology and Obstetrics > WP 400-480 Uterus. Cervix
WQ Obstetrics > WQ 200-212 Reproduction. Pregnancy
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 31-37
Journal or Publication Title: Iranian Journal of Neonatology
Journal Index: Scopus
Volume: 11
Number: 3
Identification Number: https://doi.org/10.22038/ijn.2020.41505.1682
ISSN: 22517510 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/692

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