Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Effect of troxerutin on oxidative stress induced by sciatic nerve ischemia-reperfusion injury in rats

(2020) Effect of troxerutin on oxidative stress induced by sciatic nerve ischemia-reperfusion injury in rats. Journal of Kerman University of Medical Sciences. pp. 338-347. ISSN 10239510 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Troxerutin has antioxidant and anti-inflammatory properties and in this study, its antioxidant effect on the reduction of oxidative stress induced by ischemia-reperfusion sciatic nerve injury was investigated. Methods: In this study, 64 male rats were randomly divided into 8 groups as follows: 1- IR2: ischemia (3 hours) and reperfusion (2 days), 2- Trox+IR2: ischemia (3 hours) and reperfusion (2 days), 3- IR7: ischemia (3 hours) and reperfusion (7 days), 4- Trox+IR7: ischemia (3 hours) and reperfusion (7 days), 5- IR14: ischemia (3 hours) and reperfusion (14 days), 6- Trox+IR14: ischemia (3 hours) and reperfusion (14 days), 7- IR28: ischemia (3 hours) and reperfusion (28 days), 8- Trox+IR28: ischemia (3 hours) and reperfusion (28 days). The rats received 150 mg/kg troxerutin in one injection (single dose). After separation of serum, biochemical parameters of the serums such as NO, PONI, CAT, and GPX were measured. Results: Troxerutin significantly increased the GPX and PON1 levels in groups that their reperfusion time was 2 and 14 days (P<0.05). There was no significant difference in the levels of NO and CAT between the groups received troxerutin and control groups (P>0.05). Conclusion: Troxerutin relatively decreased the oxidative stress in the sciatic nerve ischemia-reperfusion injury by increasing the level of antioxidant enzymes. © 2020, Kerman University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Ischemia-reperfusion Rat Sciatic nerve Troxerutin
Subjects: QS Human Anatomy > QS504-532 Histology
QV Pharmacology > QV 701-835 Pharmacy and Pharmaceutics
QY Clinical Laboratory Pathology > QY 50-60 Laboratory Animals
Page Range: pp. 338-347
Journal or Publication Title: Journal of Kerman University of Medical Sciences
Journal Index: Scopus
Volume: 27
Number: 4
ISSN: 10239510 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/691

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