Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats

(2020) Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats. JBRA assisted reproduction. ISSN 1518-0557 (Electronic) 1517-5693 (Linking)

[img] Text

Download (865kB)

Official URL:


OBJECTIVE: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM, including medicinal herbs. Our study aimed to evaluate the role of Pistacia atlantica's extract in the protection against ovary damage by streptozotocin (STZ)-induced DM in rats. METHODS: We ran this experimental study on 40 adult female Wistar rats. We divided the animals into five groups, control (A); DM (STZ by 60 mg/kg- intraperitoneally) (B); DM + hexane extract of P. atlantica (200 mg/kg -orally) (C); P. atlantica extract (D) and DM + glibenclamide (200 mg/kg -orally) (F). The experiment continued for four weeks, and we administered the extract daily. After slaughtering the rats, we removed the ovaries. We assessed parameters, such as blood glucose and levels of oxidative stress markers as well as histological ovary structure. RESULTS: Blood glucose, malondialdehyde (MDA) levels, and the number of atretic follicles were elevated; catalase (CAT), superoxide dismutase (SOD) levels and the number of corpora lutea were significantly decreased in the untreated diabetic rats. These changes returned to normal or diminished with P. atlantica extract and glibenclamide in the treated rats. CONCLUSIONS: The extract of P. atlantica has antihyperglycemic and antioxidative properties, and it decreased ovarian complications in experimental diabetes mellitus.

Item Type: Article
Keywords: Pistacia atlantica extract diabetes ovary rat
Subjects: QS Human Anatomy > QS504-532 Histology
QY Clinical Laboratory Pathology > QY 50-60 Laboratory Animals
WP Gynecology and Obstetrics > WP 505-560 Physiology
WQ Obstetrics > WQ 200-212 Reproduction. Pregnancy
Journal or Publication Title: JBRA assisted reproduction
Journal Index: Pubmed
Identification Number:
ISSN: 1518-0557 (Electronic) 1517-5693 (Linking)
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item