Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Different Pharmacokinetic Response to an Acute Dose of Inorganic Nitrate in Patients with Type 2 Diabetes

(2020) Different Pharmacokinetic Response to an Acute Dose of Inorganic Nitrate in Patients with Type 2 Diabetes. Endocrine, metabolic & immune disorders drug targets. ISSN 2212-3873 (Electronic) 1871-5303 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32787767

Abstract

AIM: We aimed to compare the pharmacokinetics of nitrate (NO3) in patients with type 2 diabetes mellitus (T2DM) and healthy adults. Potential effects of salivary nitrate reductase (NR) activity on cardiometabolic responses to an acute dose of NO3 was also assessed. METHODS: Nine healthy adults and nine T2DM patients were recruited to consume a NO3-rich breakfast (~410 mg NO3). Pharmacokinetics of NO3 were examined using repeated measurements of NOx (nitrate+nitrite) concentrations of serum and saliva over 8 hours and NO3 concentrations of spot and 24-h urine samples. Cardiometabolic parameters including serum levels of glucose, insulin, and triglycerides as well as blood pressures were also measured. RESULTS: Compared to patients with T2DM, serum NOx concentration (Delta1= 16.7 vs. 4.4 micromol/L, P=0.057) of healthy subjects sharply increased within 1 hour after NO3 loading. Healthy subjects had a higher NR activity index, and higher peak salivary NO3 concentration with a lower time to peak. Diabetic patients with high- compared to low-NR values had a higher whole-body NOx exposure (103+/-31.4 vs. 58.9+/-22.1 micromol*h/L); they also showed a better glycemic response and more reduction of blood pressure following ingestion of a NO3-rich meal. CONCLUSION: T2DM may be associated with a different pattern of NOx pharmacokinetics (especially salivary NOx metabolism). Salivary NR activity may have a critical role in postprandial metabolism of NO3, and diabetic patients with higher NR activity may take more advantages from NO3 supplementation.

Item Type: Article
Keywords: Beetroot nitrate nitric oxide nitrite pharmacokinetics type 2 diabetes mellitus
Subjects: QT Physiology > QT104-172 Human Physiology
QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body
QU Biochemistry. Cell Biology and Genetics > QU 135-144 Enzymes
WB Practice of Medicine > WB 300-962Therapeutics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Clinical Biochemistry
Journal or Publication Title: Endocrine, metabolic & immune disorders drug targets
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/1871530320666200813135251
ISSN: 2212-3873 (Electronic) 1871-5303 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/682

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