Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/K-ATP channel pathway and PPAR gamma receptors

(2020) Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/K-ATP channel pathway and PPAR gamma receptors. International Journal of Neuroscience. p. 8. ISSN 0020-7454

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Abstract

Objective: The leukotrienes are inflammatory mediators. In the present study, the analgesic role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible involvement of L-arginine/NO/cGMP/K-ATP channel pathway and PPAR gamma receptors was assessed in the formalin test in rats. Methods and results: The local administration of montelukast into the hind paw produced dose-related analgesia during both phases of the formalin test. Furthermore, pre-treatment with L-NAME, methylene blue, and glibenclamide prevented montelukast (10 mu g/paw)-induced antinociception in both early and late phases of the test. Moreover, the local L-arginine and diazoxide before the sub-effective dose of montelukast (3 mu g/paw) produced an analgesic effect. Also, local GW-9662 blocked antinociception induced by montelukast plus pioglitazone (10 mu g/paw). Conclusion: In conclusion, montelukast produced peripheral analgesia through PPAR gamma receptors and activation of the L-arginine/NO/cGMP/K-ATP channel pathway, with potential for a new topical analgesic drug.

Item Type: Article
Keywords: Montelukast local antinociception L-arginine/NO/cGMP/KATP channel PPAR gamma receptors formalin test rat nitric-oxide release formalin assay role k+ channels ellagic acid cyclic-gmp morphine activation involvement prevents inflammation Neurosciences & Neurology
Subjects: QS Human Anatomy > QS504-532 Histology
QU Biochemistry. Cell Biology and Genetics > QU 75-99 Carbohydrates. Lipids
QV Pharmacology > QV 76-113 Central Nervous System Agents. Local Anesthetics
QY Clinical Laboratory Pathology > QY 50-60 Laboratory Animals
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 200-226 Metabolic Diseases
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Toxicology and Pharmacology
Page Range: p. 8
Journal or Publication Title: International Journal of Neuroscience
Journal Index: ISI
Identification Number: https://doi.org/10.1080/00207454.2020.1769618
ISSN: 0020-7454
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/673

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