Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Effects of Maternal Immune System Status on Neonate's Immune System

(2020) Effects of Maternal Immune System Status on Neonate's Immune System. Iranian Journal of Neonatology. pp. 31-37. ISSN 2251-7510

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Abstract

Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate's immune system. Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate's humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study. Results: The spleen's mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P <= 0.05) in the anti-sheep red blood cells antibody titer. Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate's immune responses, spleen, liver, and thymus development.

Item Type: Article
Keywords: Immune response Maternal Neonate Rat prenatal stress pregnancy stimulation cytokines leukocytes brain alpha cells il-4 live Pediatrics
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
WA Public Health > WA 300-395 Health Issues of Special Population Groups
WL Nervous System > WL 103-108 Psychophysiology. Neuroscience Specialties
WP Gynecology and Obstetrics > WP 505-560 Physiology
WS Pediatrics > WS 103-105 Growth and Development
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 31-37
Journal or Publication Title: Iranian Journal of Neonatology
Journal Index: ISI
Volume: 11
Number: 3
Identification Number: https://doi.org/10.22038/ijn.2020.41505.1682
ISSN: 2251-7510
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/672

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