Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/KATP channel pathway and PPARγ receptors

(2020) Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/KATP channel pathway and PPARγ receptors. International Journal of Neuroscience. ISSN 00207454 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Objective: The leukotrienes are inflammatory mediators. In the present study, the analgesic role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible involvement of L-arginine/NO/cGMP/KATP channel pathway and PPARγ receptors was assessed in the formalin test in rats. Methods and results: The local administration of montelukast into the hind paw produced dose-related analgesia during both phases of the formalin test. Furthermore, pre-treatment with L-NAME, methylene blue, and glibenclamide prevented montelukast (10 μg/paw)-induced antinociception in both early and late phases of the test. Moreover, the local L-arginine and diazoxide before the sub-effective dose of montelukast (3 μg/paw) produced an analgesic effect. Also, local GW-9662 blocked antinociception induced by montelukast plus pioglitazone (10 μg/paw). Conclusion: In conclusion, montelukast produced peripheral analgesia through PPARγ receptors and activation of the L-arginine/NO/cGMP/KATP channel pathway, with potential for a new topical analgesic drug. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Keywords: formalin test L-arginine/NO/cGMP/KATP channel local antinociception Montelukast PPARγ receptors rat
Subjects: QV Pharmacology > QV 701-835 Pharmacy and Pharmaceutics
QV Pharmacology > QV 76-113 Central Nervous System Agents. Local Anesthetics
QY Clinical Laboratory Pathology > QY 50-60 Laboratory Animals
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology
Journal or Publication Title: International Journal of Neuroscience
Journal Index: Scopus
Identification Number: https://doi.org/10.1080/00207454.2020.1769618
ISSN: 00207454 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/652

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