Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/KATP channel pathway and PPARgamma receptors

(2020) Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/KATP channel pathway and PPARgamma receptors. The International journal of neuroscience. pp. 1-8. ISSN 1563-5279 (Electronic) 0020-7454 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/32408781

Abstract

Objective: The leukotrienes are inflammatory mediators. In the present study, the analgesic role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible involvement of L-arginine/NO/cGMP/KATP channel pathway and PPARgamma receptors was assessed in the formalin test in rats.Methods and results: The local administration of montelukast into the hind paw produced dose-related analgesia during both phases of the formalin test. Furthermore, pre-treatment with L-NAME, methylene blue, and glibenclamide prevented montelukast (10 mug/paw)-induced antinociception in both early and late phases of the test. Moreover, the local L-arginine and diazoxide before the sub-effective dose of montelukast (3 mug/paw) produced an analgesic effect. Also, local GW-9662 blocked antinociception induced by montelukast plus pioglitazone (10 mug/paw).Conclusion: In conclusion, montelukast produced peripheral analgesia through PPARgamma receptors and activation of the L-arginine/NO/cGMP/KATP channel pathway, with potential for a new topical analgesic drug.

Item Type: Article
Keywords: L-arginine/NO/cGMP/KATP channel Montelukast PPARgamma receptors formalin test local antinociception rat
Subjects: QV Pharmacology > QV 701-835 Pharmacy and Pharmaceutics
QY Clinical Laboratory Pathology > QY 50-60 Laboratory Animals
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Toxicology and Pharmacology
Page Range: pp. 1-8
Journal or Publication Title: The International journal of neuroscience
Journal Index: Pubmed
Identification Number: https://doi.org/10.1080/00207454.2020.1769618
ISSN: 1563-5279 (Electronic) 0020-7454 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/645

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