Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

INVOLVEMENT OF HAPTOGLOBIN PHENOTYPES AND GENOTYPES IN NON-MUSCLE INVASIVE BLADDER CANCER: A POSSIBLE PROGNOSTIC MARKER FOR RISK STRATIFICATION

(2020) INVOLVEMENT OF HAPTOGLOBIN PHENOTYPES AND GENOTYPES IN NON-MUSCLE INVASIVE BLADDER CANCER: A POSSIBLE PROGNOSTIC MARKER FOR RISK STRATIFICATION. Excli Journal. pp. 351-359. ISSN 1611-2156

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Abstract

The association of haptoglobin (Hp) with various cancers has been reported and also it has been documented that the Hp phenotypes/genotypes have different functional ability. So, we examined phenotypes/genotypes of Hp in newly diagnosed, untreated non-muscle invasive bladder cancer (NMIBC) patients and investigated its prognostic value for risk stratification of the cancer. In eighty NMIBC patients and 80 healthy individuals the Hp genotypes and phenotypes were analyzed using polymerase chain reaction (PCR) and two-dimensional gel electrophoresis (2D-GE), respectively. Besides, the presence of the Hp alpha 1, alpha 2, and beta chains in the sera was confirmed by Mass Spectrometry (MS). The frequencies of the 1-1 and 2-2 genotypes/phenotypes were respectively higher and lower in healthy subjects compared to the patients. Our results revealed that the 2-2 genotype/phenotype could increase the risk of NMIBC. There was a positive association between the 2-2 genotype/phenotype with the T category/grade of cancer (p<0.05). The present study implied a strong association between the Hp phenotypes and genotypes with NMIBC. It was found that the 2-2 genotype and phenotype could be a risk factor for NMIBC incidence, as well as, progression. This study introduced Hp genotyping as a possible cost-effective and precise method for prognosis of individuals at the risk of NMIBC.

Item Type: Article
Keywords: Haptoglobin acute-phase protein biomarkers non-muscle invasive bladder cancer electrophoresis serum haptoglobin polymorphism association Life Sciences & Biomedicine - Other Topics
Subjects: QZ Pathology > QZ 200-380 Neoplasms
WJ Urogenital System > WJ 400-600 Ureter. Bladder. Urethra
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Pathology
Page Range: pp. 351-359
Journal or Publication Title: Excli Journal
Journal Index: ISI
Volume: 19
Identification Number: https://doi.org/10.17179/excli2019-1768
ISSN: 1611-2156
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/638

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