Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Aloe vera ameliorates ovarian toxicity induced by bisphenol a in wistar rats

(2018) Aloe vera ameliorates ovarian toxicity induced by bisphenol a in wistar rats. Journal of Zanjan University of Medical Sciences and Health Services. pp. 17-23. ISSN 16069366 (ISSN)

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Abstract

Background & Objective: Bisphenol A (BPA) is a hazardous environmental pollutant, which is known to cause ovarian toxicity. The present study aimed to assess the protective effects of Aloe vera herbal extract against ovarian toxicity caused by BPA in Wistar rats. Materials & Methods: The sample population of this experimental study consisted of 40 adults female Wistar rats with a mean weight of 200±20 grams. The test animals were investigated in five groups after synchronizing, including one control group and one vehicle group (olive oil 5 ml/kg b.wt./day). Rats in the experimental groups were administered with various oral doses of BPA and Aloe vera extract daily for eight consecutive weeks (400 mg Aloe vera gel/kg b.wt./day, 10 mg BPA/kg b.wt./day dissolved in 5 ml/kg of olive oil, and BPA + Aloe vera). Blood samples (2 ml) were obtained from anesthetized rats after the intervention in order to measure the levels of oxidative stress markers and sex hormones. Moreover, the researchers collected both ovaries for histological examinations. Results: BPA decreased estradiol levels significantly (P<0.05). In addition, while thiol protein (G-SH) and total antioxidant capacity (TAC) decreased, malondialdehyde (MDA) showed an increase. Fewer corpus luteum and antral follicles, more atretic follicles and several cysts were observed in histopathological results of BPA group. But total antioxidant capacity and ovarian tissue healing structure were accelerated by coadministration of Aloe vera with BPA. Conclusion: According to the results, the use of herbal extract of Aloe vera could significantly inhibit the debilitating effects of BPA on the reproduction of female rats. Moreover, Aloe Vera gel exerted protective effects against folliculogenesis, stimulating the production of hormones to prevent the toxicity caused by BPA. © 2018, Zanjan University of Medical Sciences and Health Services. All rights reserved.

Item Type: Article
Keywords: Aloe vera Bisphenol A Ovary Rats 4,4' isopropylidenediphenol Aloe vera extract biochemical marker malonaldehyde protective agent sex hormone adult animal experiment animal housing animal model animal tissue antioxidant activity antral follicle Article biochemical analysis controlled study corpus luteum enzyme linked immunosorbent assay estradiol blood level experimental toxicity female granulosa cell high performance liquid chromatography histopathology hormonal regulation infertility morphometry nonhuman ovarian toxicity ovary disease ovary follicle development ovary polycystic disease oxidative stress progesterone blood level rat
Subjects: QS Human Anatomy > QS504-532 Histology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 17-23
Journal or Publication Title: Journal of Zanjan University of Medical Sciences and Health Services
Journal Index: Scopus
Volume: 26
Number: 119
Identification Number: https://doi.org/10.352/jambr.26.119.17
ISSN: 16069366 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/621

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