Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Antioxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticles on streptozotocin-nicotinamideinduced diabetic nephropathy in type 2 diabetic male mice

(2019) Antioxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticles on streptozotocin-nicotinamideinduced diabetic nephropathy in type 2 diabetic male mice. Iranian Journal of Basic Medical Sciences. pp. 1424-1431. ISSN 20083866 (ISSN)

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Abstract

Objective(s): The present study evaluates the protective effects of myricitrin and its solid lipid nanoparticle (SLN) on diabetic nephropathy (DN) induced by streptozotocin-nicotinamide (STZ-NA) in mice. Materials and Methods: In this experimental study, 108 adult male NMRI mice were divided into 9 groups: control, vehicle, diabetes, diabetes + myricitrin 1, 3, and 10 mg/kg and, diabetes + SLN containing myricitrin 1, 3, and 10 mg/kg. After the experimental period, the plasma and tissue samples were collected for experimental, histopathological, real-time PCR and apoptosis assessments. Results: Total antioxidant capacity, catalase, glomerular filtration rate, plasma level of albumin, urine (BUN) and, creatinine (Cr) levels decreased, and the kidney weight, intake/output, malondialdehyde, plasma level of BUN and Cr, urine level of sodium, potassium, albumin and glucose, fractional excretions of sodium and potassium, transforming growth factor-ß (TGF-ß) and nuclear factor kappa B (NF-κB) gene expression, red blood cell accumulation and infiltration of inflammatory cells, and kidney apoptosis increased in untreated diabetic mice compared to the control group, and administration of myricitrin and its SLN recovered all of these changes. Conclusion: Ultimately, myricitrin and its SLN administration improved DN changes by reducing oxidative stress and increasing antioxidant enzymes level, and these effects were more prominent in the SLN-administered mice. © 2019 Mashhad University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Anti-apoptotic Antioxidant Diabetic nephropathy Mice Myricitrin Solid lipid nanoparticle
Subjects: QS Human Anatomy > QS504-532 Histology
QT Physiology > QT104-172 Human Physiology
QV Pharmacology > QV 310-325 Noble Gases. Oxygen. Antioxidants
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology
Page Range: pp. 1424-1431
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: Scopus
Volume: 22
Number: 12
Identification Number: https://doi.org/10.22038/ijbms.2019.13989
ISSN: 20083866 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/615

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