Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds

(2019) Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds. Oxidative Medicine and Cellular Longevity. p. 10. ISSN 1942-0900

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Abstract

Berberis vulgaris is a well-known herb in Iran that is widely used as a medicinal plant and a food additive. The aim of this study was to investigate the anti-inflammatory and immunomodulatory effects of Barberry and its main compounds. This narrative review was conducted by searching keywords such as B. vulgaris, Barberry, immunomodulatory, anti-inflammatory, medicinal herbs, plants, and extract, separately or combined in various databases, such as Web of Sciences, PubMed, and Scopus. According to the inclusion and exclusion criteria, just English language articles, which reported effective whole plants or herbal compounds, were included. 21 articles were reviewed in this study. In the in vivo models (mice, rats, and human cells) and in the in vitro models (some organ cells such as the spleen, kidney, blood, and brain), B. vulgaris and its main components showed anti-inflammatory effects in both models. The main mechanisms were the shift of cell immune response to Th2, T reg induction, inhibition of inflammatory cytokines (IL-1, TNF, and IFN-gamma), and stimulation of IL-4 and IL-10. The induction of apoptosis in APCs and other effector cells was another important mechanism.

Item Type: Article
Keywords: mouse macrophages medicinal-plants extract cells rats degradation antioxidant splenocytes inhibition induction Cell Biology
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Toxicology and Pharmacology
Page Range: p. 10
Journal or Publication Title: Oxidative Medicine and Cellular Longevity
Journal Index: ISI
Volume: 2019
Identification Number: https://doi.org/10.1155/2019/6183965
ISSN: 1942-0900
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/582

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