Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Drug Resistance Patterns in HIV Patients with Virologic Failure in Iran

(2019) Drug Resistance Patterns in HIV Patients with Virologic Failure in Iran. Archives of Clinical Infectious Diseases. p. 5. ISSN 2345-2641

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Abstract

We reviewed the medical charts of 1,700 patients diagnosed with HIV who referred to a central HIV clinic in Tehran between 2004 and 2017. Participants who had a viral load of > 200 copies/mL after six months or more on antiretroviral therapy (ART) were grouped as virologic failure (VF). We assessed the demographic characteristics, diagnosis date, first ART regimen, and resistance to various ART drugs. Out of 1,700 patients, 72 (4.2) had a treatment failure. Among those with treatment failure, 51.3 were on zidovudine + lamivudine + efavirenz, 18.1 were on tenofovir + lamivudine + lopinavir/ritonavir, and 12.5 were on tenofovir + emtricitabine + efavirenz. In patients with treatment failure, the highest resistance was to nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs) combination (44.4). In these patients, resistance to tenofovir (one of the NRTIs) was 29.1. The highest treatment failure was observed among patients treated with nevirapine (NVP) and efavirenz (EFV)-based regimen. Our findings suggest that protease inhibitors should be considered as first-line drugs in ART regimens in VF patients in Iran.

Item Type: Article
Keywords: HIV/AIDS Virologic Failure Antiretroviral Therapy Iran antiretroviral therapy experienced patients adherence mutations infection hiv/aids barriers naive Infectious Diseases
Subjects: WC Communicable Diseases > WC 500-590 Virus Diseases
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Page Range: p. 5
Journal or Publication Title: Archives of Clinical Infectious Diseases
Journal Index: ISI
Volume: 14
Number: 6
Identification Number: https://doi.org/10.5812/archcid.96531
ISSN: 2345-2641
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/575

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