Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

PD-1/PD-L1-dependent immune response in colorectal cancer

(2020) PD-1/PD-L1-dependent immune response in colorectal cancer. Journal of Cellular Physiology. p. 15. ISSN 0021-9541

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Abstract

Colorectal cancer (CRC) is still considered as the third most frequent cancer in the world. Microsatellite instability (MSI), inflammation, and microRNAs have been demonstrated as the main contributing factors in CRC. Subtype 1 CRC is defined by NK cells infiltration, induction of Th1 lymphocyte and cytotoxic T cell responses as well as upregulation of immune checkpoint proteins including programmed cell death-1 (PD-1). Based on the diverse features of CRC, such as the stage and localization of the tumor, several treatment approaches are available. However, the efficiency of these treatments may be decreased due to the development of diverse resistance mechanisms. It has been proven that monoclonal antibodies (mAbs) can increase the effectiveness of CRC treatments. Nowadays, several mAbs including nivolumab and pembrolizumab have been approved for the treatment of CRC. Immune checkpoint receptors including PD-1 can be inhibited by these antibodies. Combination therapy gives an opportunity for advanced treatment for CRC patients. In this review, an update has been provided on the molecular mechanisms involved in MSI colorectal cancer immune microenvironment by focusing on PD-ligand 1 (PD-L1) and treatment of patients with advanced immunotherapy, which were examined in the different clinical trial phases. Considering induced expression of PD-L1 by conventional chemotherapeutics, we have summarized the role of PD-L1 in CRC, the chemotherapy effects on the PD-1/PD-L1 axis and novel combined approaches to enhance immunotherapy of CRC by focusing on PD-L1.

Item Type: Article
Keywords: colorectal cancer immune checkpoint receptors immunotherapy programmed cell death-1 programmed cell death-ligand 1 tumor-infiltrating lymphocytes consensus molecular subtypes pd-l1 surface expression cd8(+) t-cells checkpoint blockade mismatch-repair microsatellite instability colon-cancer photodynamic therapy antitumor immunity Cell Biology Physiology
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Immunology Department
Page Range: p. 15
Journal or Publication Title: Journal of Cellular Physiology
Journal Index: ISI
Identification Number: https://doi.org/10.1002/jcp.29494
ISSN: 0021-9541
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/568

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