Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Mechanisms and performances of adjuvants in vaccine immunogenicity

(2015) Mechanisms and performances of adjuvants in vaccine immunogenicity. Journal of Applied Biotechnology Reports. pp. 257-264. ISSN 23221186 (ISSN)

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An adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. Vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for use. The basic action of adjuvants is stimulating adaptive immune responses. Adjuvants recently licensed for human utilization involve alum squalane oil or water emulsion, influenza virosomes, and few cytokines as IFN-γ and IL-2. Some adjuvants are currently under investigation such as DNA motifs, monophosphoryl lipid A, Cholera Toxin, E. coli heat Labile Toxin, Saponins, Immunostimulating complexes, liposomes, Flt3 ligand as a pleotropic glycoprotein, non-ionic block copolymers. This paper is an overview of most commonly used adjuvants, adjuvant mechanisms, adjuvant formulations and adjuvant limitations. © 2015, Baqiyatallah university of medical sciences. All rights reserved.

Item Type: Article
Keywords: Adjuvants Alum Immunostimulating complexe MHC Vaccine
Page Range: pp. 257-264
Journal or Publication Title: Journal of Applied Biotechnology Reports
Journal Index: Scopus
Volume: 2
Number: 3
ISSN: 23221186 (ISSN)
Depositing User: مهندس مهدی شریفی

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