Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

PH-sensitive bionanocomposite hydrogel beads based on caborboxymethyl cellulose/ZnO nanoparticle as drug carrier

(2016) PH-sensitive bionanocomposite hydrogel beads based on caborboxymethyl cellulose/ZnO nanoparticle as drug carrier. International Journal of Biological Macromolecules. pp. 1317-1327. ISSN 01418130 (ISSN)

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Official URL: https://www2.scopus.com/inward/record.uri?eid=2-s2...

Abstract

The present work explains the preparation of new pH-sensitive bionanocomposite beads based on carboxymethyl cellulose (CMC) and ZnO nanoparticles for use as controlled release drug delivery systems. Fe3+ ion as physical crosslinking agent was used to prepare ionic cross-linked bionanocomposite hydrogel beads. Propranolol hydrochloride (PPN) has been chosen as a model drug. Characterization of the pH-sensitive bionanocomposite beads resulting from incorporation of different content of ZnO nanoparticles into CMC matric was carried out using different experimental techniques: XRD, FT-IR, TGA, SEM and EDX. Propranolol incorporation efficiency in beads was determined by UV–vis spectroscopy and was found to be high. Moreover, the swelling and drug release properties of the bionanocomposite hydrogels were investigated. The prepared bionanocomposite beads showed a pH sensitive swelling behavior with maximum water absorbing at pH 7.4. Also, it was found that the swelling ratio of ZnO/CMC hydrogels in different aqueous solutions was rather higher in comparison with its neat hydrogel. In vitro drug release test was carried out to prove the effectiveness of this novel type of bionanocomposite hydrogel beads as a controlled drug delivery system. A more sustained and controlled drug releases were observed for ZnONPs containing NaCMC beads, which increased by the increase in ZnONPs content. © 2016

Item Type: Article
Keywords: Carboxymethyl cellulose hydrogel Drug carrier pH-sensitive ZnO nanoparticles biopolymer carboxymethylcellulose ferric ion nanocomposite propranolol zinc oxide nanoparticle hydrogel microsphere nanoparticle zinc oxide aqueous solution Article controlled drug release cross linking infrared spectroscopy pH scanning electron microscopy sustained drug release thermogravimetry ultraviolet spectrophotometry water absorption X ray diffraction chemistry drug release mechanics temperature Carboxymethylcellulose Sodium Drug Carriers Drug Liberation Mechanical Phenomena Microspheres Nanocomposites Nanoparticles
Page Range: pp. 1317-1327
Journal or Publication Title: International Journal of Biological Macromolecules
Journal Index: Scopus
Volume: 93
Identification Number: https://doi.org/10.1016/j.ijbiomac.2016.09.110
ISSN: 01418130 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/477

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