Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Memantine Enhances the Effect of Olanzapine in Patients With Schizophrenia: A Randomized, Placebo-Controlled Study

(2016) Memantine Enhances the Effect of Olanzapine in Patients With Schizophrenia: A Randomized, Placebo-Controlled Study. Acta medica Iranica. pp. 696-703. ISSN 1735-9694 (Electronic) 0044-6025 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/28033691

Abstract

Glutamate dysregulation may be involved in the neuropathology of schizophrenia. Memantine, a drug approved by the FDA for the treatment of moderate to severe Alzheimer's disease, acts as a partial uncompetitive NMDA receptor antagonist. The aim of this study was to examine the efficacy of memantine as an adjunctive treatment to olanzapine in patients with schizophrenia. In this double-blind, placebo-controlled studies, patients with schizophrenia according to DSM-IV clinical criteria were selected. Patients were randomly assigned to receive either memantine (week 1:10 mg/day; weeks 2-6:20 mg/day) plus olanzapine (15-20 mg/day) or olanzapine plus placebo. At baseline, no statistically significant difference regarding the mean total PANSS scores between treatment groups was found. Results showed that memantine significantly improved the positive and negative PANSS score in patients maintained on olanzapine after six weeks compared to olanzapine alone (P<0.001). Furthermore, female patients showed significantly better response than males, especially in positive PANSS score. No significant changes in extrapyramidal symptoms were observed.These findings indicate that olanzapine efficacy might be augmented with memantine. Furthermore, this effect is more remarkable in female patients with schizophrenia.

Item Type: Article
Keywords: Adolescent Adult Antipsychotic Agents/administration & dosage Benzodiazepines/*administration & dosage Dose-Response Relationship, Drug Double-Blind Method Excitatory Amino Acid Antagonists/administration & dosage Female Follow-Up Studies Humans Male Memantine/*administration & dosage Middle Aged Olanzapine Schizophrenia/*drug therapy Time Factors Treatment Outcome Young Adult Combination therapy Gender Memantine NMDA receptors Schizophrenia
Page Range: pp. 696-703
Journal or Publication Title: Acta medica Iranica
Journal Index: Pubmed
Volume: 54
Number: 11
ISSN: 1735-9694 (Electronic) 0044-6025 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/397

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