Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model

(2015) Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model. Evidence-Based Complementary and Alternative Medicine. p. 4. ISSN 1741-427X

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Abstract

Delayed wound healing process is one of the most important concerns in diabetes. Healing of wounds has four phases, namely, hemostasis, inflammation, proliferation, and remodeling. For a successful repair, all four factors must occur properly. Hence, we aimed to evaluate the healing effects of Hypericum perforatum (HP) on full-thickness diabetic skin wounds by using stereological methods. Forty-eight female diabetic rats were randomly divided into four groups (n = 12): gel base treated group, HP 5 gel treated group, HP 10 gel treated group, and the control group which received no treatment. A circular 1 cm(2) full-thickness wound was created on the animal's neck and wound area was measured every three days. After sacrificing the animals, skin samples were fixed and prepared for stereological evaluations. Based on the results, HP treated group showed faster wound closure rate in comparison with control and vehicle groups (P < 0.05). In addition, numerical density of fibroblasts, volume density of collagen bundles, and mean diameter and volume densities of the vessels in HP group were significantly higher than control and vehicle groups. The results of this study showed that HP has the ability to improve tissue regeneration by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization.

Item Type: Article
Keywords: st-johns-wort antibacterial activity growth bacteria foot l. Integrative & Complementary Medicine
Page Range: p. 4
Journal or Publication Title: Evidence-Based Complementary and Alternative Medicine
Journal Index: ISI
Identification Number: https://doi.org/10.1155/2015/245328
ISSN: 1741-427X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/335

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