Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain

(2016) Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain. European Journal of Pharmacology. pp. 38-45. ISSN 0014-2999

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Abstract

This study aimed to investigate the involvement of opioid receptors in the systemic and peripheral antinociceptive activities of montelukast in different animal models of pain. Rats and mice were injected with montelukast to produce analgesia. The formalin and acetic acid induced writhing tests were used to assess the nociceptive activity. The results showed that i.p. administration of montelukast (0.3-10 mg/kg) dose-dependently reduced flinching behavior in both the first and second phases of formalin test with mean ED50, of 0.55 and 5.31 mg/kg, respectively. Also, intraplantar administration of montelukast (3-30 mu g/paw) produced antinociception against the two phases of formalin assay in a dose-dependent way with mean ED.30 of 2.92 and 8.11 pg/paw, respectively. Furthermore, pre-treatment with naloxone (a non-selective opioid receptor antagonist) significantly inhibited both the systemic and also peripheral antinociceptive actions of montelukast in formalin test. In writhing test, the results showed that intraperitoneal administration of montelukast (3-10 mg/kg) significantly reduced the writhe number induced by acetic acid in mice. Moreover, co-administration of non-effective doses of montelukast (0.3 and 1 mg/kg; i.p.) and morphine (0.25 mg/kg; i.p.) significantly decreased the writhes number induced by acetic acid. Also, this effect was naloxone-reversible. These findings suggest that the systemic and peripheral antinociception produced by montelukast were mediated through the opioid receptors in central and peripheral nervous systems. Moreover, combination of montelukast and morphine could be noted as a new strategy for pain relief. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Antinociception Montelukast Opioid receptors Potentiation Formalin test Wrighting formalin test ellagic acid mice leukotriene rat activation dependence morphine sensitization lipoxygenase Pharmacology & Pharmacy
Page Range: pp. 38-45
Journal or Publication Title: European Journal of Pharmacology
Journal Index: ISI
Volume: 779
Identification Number: https://doi.org/10.1016/j.ejphar.2016.03.010
ISSN: 0014-2999
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/314

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