Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

SIPA1L2, MIR4697, GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case -control study

(2016) SIPA1L2, MIR4697, GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case -control study. Journal of the Neurological Sciences. pp. 1-4. ISSN 0022-510X

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Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Prevalence of PD increases steadily with age. A recent meta-analysis of genome-wide association studies has identified six new loci to be linked with PD. Here we investigated the association of four of these new loci, S1PA1L2, MIR4697, GCH1 and VPS13C with PD in an Iranian population. Through a case-control study a total of 1800 subjects comprising 600 PD patients and 1200 unrelated healthy controls were recruited. Rsl 0797576, rs329648, rs11158026 and rs2414739 related to SIPA1L2, MIR4697, GCH1 and VPS13C loci respectively, were genotyped in all subjects. The difference of genotype and allele frequencies between case and control groups were investigated using chisquare test and logistic regression models with R software. Genotype and allele frequencies were significantly different in PD patients and control group for rs329648, rs11158026 and rs2414739 (p-value = 0.018, 0.025, and 0.009 respectively for allele frequency differences). There was no difference in genotype nor allele frequencies between the two groups for rs10797576. We replicated the association of three new loci which are proposed for PD. More studies in other populations and also functional analysis are required to clear the role of these variants in PD. (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Parkinson's disease Polymorphism Iranian population GCH1 MIR4697 VPS13C dopa-responsive dystonia association gene variant Neurosciences & Neurology
Page Range: pp. 1-4
Journal or Publication Title: Journal of the Neurological Sciences
Journal Index: ISI
Volume: 369
Identification Number: https://doi.org/10.1016/jjns.2016.08.001
ISSN: 0022-510X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/300

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