Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Accumulation of Iron Oxide Nanoparticle and Conventional Iron Oxide in Rat Ovary and Oxidative Stress Caused by It

(2018) Accumulation of Iron Oxide Nanoparticle and Conventional Iron Oxide in Rat Ovary and Oxidative Stress Caused by It. Iranian Red Crescent Medical Journal. p. 6. ISSN 2074-1804

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Abstract

Background: Iron is one of the most essential elements of life that plays a major role in structure of the most cells of body and is potentially toxic and dangerous, because it easily participates in oxidation-reduction reactions and produces reactive oxygen species, which leads to oxidative stress; nanomaterials such as iron nanoparticles found in environmental pollution and can also be dangerous. Objectives: The current study aimed at evaluating and comparing the effects of accumulation of conventional iron oxide and iron oxide nanoparticles in rat ovary and its relationship with serum oxidative stress. Methods: The current experimental study was conducted on 5 groups of female rats, control, iron oxide (15 mg/kg), and iron oxide nanoparticles (5, 15, and 45 mg/kg). All rats were treated intraperitoneally for 16 days. Then, they were euthanized and their ovarian tissue was removed, and iron accumulation in the ovaries was measured by atomic absorption. Malondialdehyde (MDA), carbonyl protein, thiol protein, and total antioxidant activity were also measured in rats serum samples. Results: According to the current study findings, iron accumulation increased significantly (P = 0.046) in the group that received conventional iron oxide, as compared with the control group. Also, the mean of total antioxidant activity (4.4 +/- 294.31 mu M/L) and thiol protein (3.3 +/- 381.09 mu m/mL) showed a significant (P <= 0.05) differences in group that received conventional iron oxide, compared with the other groups, MDA and protein carbonyl had no significant (P >= 0.05) difference. Conclusions: According to the findings, conventional iron oxide particle induced more accumulation and more oxidative stress than nanoparticles.

Item Type: Article
Keywords: Iron Oxide Oxidative Stress Ovary Rat nonheme iron antioxidant metabolism apoptosis toxicity cells General & Internal Medicine
Subjects: QS Human Anatomy > QS504-532 Histology
QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: p. 6
Journal or Publication Title: Iranian Red Crescent Medical Journal
Journal Index: ISI
Volume: 20
Number: 1
Identification Number: https://doi.org/10.5812/ircmj.58738
ISSN: 2074-1804
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/211

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