Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Prebiotic prophylaxis of ventilator-associated pneumonia: A randomized clinical trial

(2018) Prebiotic prophylaxis of ventilator-associated pneumonia: A randomized clinical trial. Biomedical Research and Therapy. pp. 2287-2295. ISSN 2198-4093

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Introduction: There is evidence of the curing effects of prebiotics in promoting growth of bifid bacterium in the digestive system and the central role of bacteria colonization in the pathogenesis of ventilator-associated pneumonia (VAP). The purpose of this study was to evaluate the effects of administration of a prebiotic, namely fenugreek seeds, on VAP prevention and clinical outcomes in critically ill patients. Methods: In this study, 60 mechanically ventilated patients were randomly divided into 2 groups (n=30 per group). Group 1 was given fenugreek seed powder by gavage, twice a day in addition to routine care, while group 2 received only routine care. Demographic and clinical data were recorded and clinical responses to the primary component (prevalence of VAP) and secondary component (other clinical factors) were interpreted. Data were analyzed via SPSS v.20, using student t-test, chi-square test, repeated measure ANOVA, and Wilcoxon test. Result: There was a significant reduction of patients diagnosed with VAP, as well as clostridium difficile-associated diarrhea and some complications of mechanical ventilation, in group 1 when compared to group 2. In addition, improvement in VAP was significantly greater for group 1 as compared with group 2. Mortality rates were not different between the two groups. Conclusion: The present study demonstrated that daily diet with fenugreek seeds can be used as an add-on therapy with other medications in prevention of VAP. As a result, the use of fenugreek seeds in the treatment plan of patients undergoing long-term intubation is recommended.

Item Type: Article
Keywords: Fenugreek seed Fenugreek seed Mechanical ventilation Prebiotic A Randomized clinical trial pulmonary syndromes fenugreek metaanalysis probiotics Research & Experimental Medicine
Subjects: QW Microbiology and Immunology > QW 1-300 Microbiology
Divisions: Education Vice-Chancellor Department > Faculty of Health > Department of Epidemiology
Page Range: pp. 2287-2295
Journal or Publication Title: Biomedical Research and Therapy
Journal Index: ISI
Volume: 5
Number: 5
Identification Number:
ISSN: 2198-4093
Depositing User: مهندس مهدی شریفی

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