Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Protective effects of Asparagus officinalis extract against Bisphenol A-induced toxicity in Wistar rats

(2018) Protective effects of Asparagus officinalis extract against Bisphenol A-induced toxicity in Wistar rats. Toxicology Reports. pp. 427-433. ISSN 2214-7500

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Abstract

Asparagus officinalis is an herbal medicine with remarkable antioxidant, anti-inflammatory, and antihepatotoxic properties. The present study aimed to investigate whether Bisphenol A (BPA) could induce histopathological changes and oxidative stress in the liver and kidney tissues of male rats. In addition, we evaluated whether the co-administration of the Asparagus officinalis extract (AOE) could prevent the possible damages. In total, 40 adult male Wistar rats with the mean weight of 200 +/- 20 grams were divided into five groups. Control subjects were placed in the first group, while group two was the vehicle (5 ml/kg bwt/day). Subjects in group three were administered with 400 mg/kg of AOE (bwt/day), group four received 10 mg/kg of BPA (bwt/day) dissolved in 5 ml/kg of olive oil, and group five received oral BPA and AOE daily for eight weeks. After the experiments, the blood, liver, and kidneys of the animals were collected and examined. Biochemical results showed a significant elevation in the levels of liver and kidney biomarkers in the BPA group (P <= 0.05). Moreover, malondialdehyde was observed to increase, while thiol protein and total antioxidant capacity decreased. Histopathological results of the BPA group indicated dilated and congested central and portal veins and inflammatory areas in the liver. In addition, renal test results showed casts in the urinary tubules and acute tubular necrosis. According to the results, the co-administration of AOE and BPA could increase the total antioxidative capability, thereby improving the function and structure of the liver and kidney tissues. Therefore, AOE is a potential protective agent against oxidative stress, liver, and kidney damage.

Item Type: Article
Keywords: Asparagus Officinalis Bisphenol A Liver Kidney Rat tetrachloride-induced hepato oxidative stress liver serum blood nephrotoxicity exposure injury life Toxicology
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QY Clinical Laboratory Pathology > QY 50-60 Laboratory Animals
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 427-433
Journal or Publication Title: Toxicology Reports
Journal Index: ISI
Volume: 5
Identification Number: https://doi.org/10.1016/j.toxrep.2018.02.010
ISSN: 2214-7500
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/182

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