Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Protective Effect of Aloe vera Extract against Bisphenol A Induced Testicular Toxicity in Wistar Rats

(2018) Protective Effect of Aloe vera Extract against Bisphenol A Induced Testicular Toxicity in Wistar Rats. Cell Journal. pp. 278-283. ISSN 2228-5806

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Objective: Bisphenol A (BPA), an endocrine-disrupting chemical, has been considered as a possible risk factor for fertility because it induces testicular toxicity. Thus, we sought to analyze the effect of Aloe vera as plant with antioxidant properties on tissues and oxidative stress parameters in male rats. Materials and Methods: In this experimental study, 50 adult male Wistar rats (200 +/- 20 g) have been used in this 56 day study. Animals were completely randomized and divided into five groups: A(1) (control), A(2) (vehicle control), A(3) (Aloe vera gel 300 mg/kg), B-1 (BPA 20 mu g/kg bw) and B-2 (Aloe vera gel+BPA). At the end of the study, the rats were anesthetized and 2 ml blood samples were obtained for evaluation of oxidative stress markers. Also, both testes were collected for histological examinations. Results: BPA significantly decreased (P< 0.05) body and testis weights. Seminiferous tubule diameter (STD) and height of seminiferous epithelium (HSE), were significantly decreased (P<0.05) in the groups receiving BPA as compared to the control. There was also a reduction in the quantity of spermatocyte and spermatids. Moreover, malondialdehyde (MDA) increased and thiol protein (G-SH) decreased. But, co-administration of Aloe vera with BPA accelerated the total antioxidant capacity and testicular tissue structure healing. Conclusion: According to our findings, Aloe vera gel extract can overcome the damaging effects of BPA on the reproductive system of rats and protects rats' testes against BPA-induced toxicity.

Item Type: Article
Keywords: Aloe vera Bisphenol A Rat Testis oxidative stress antioxidant enzymes lipid profile gel extract albino rats vitamin-c testosterone exposure Cell Biology
Subjects: QS Human Anatomy > QS504-532 Histology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 278-283
Journal or Publication Title: Cell Journal
Journal Index: ISI
Volume: 20
Number: 2
Identification Number:
ISSN: 2228-5806
Depositing User: مهندس مهدی شریفی

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