Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic

(2018) Ellagic acid: A promising protective remedy against testicular toxicity induced by arsenic. Biomedicine & Pharmacotherapy. pp. 1464-1472. ISSN 0753-3322

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Abstract

Chronic exposure to arsenic, an inducer of oxidative stress, is one of the major causes of male infertility. Therefore, the present study investigated the protective role of Ellagic acid (EA), as a natural antioxidant, against testicular toxicity evoked by arsenic. Thirty-five male Wistar rats were divided into 5 treatment groups. Group 1 served as control, group 2 were orally exposed to sodium arsenite (SA, 10 mg/kg; 21 days), groups 3 and 4 were initially exposed to SA for 7 days and then were treated with both EA (10 and 30 mg/kg) and SA up to 21 days, and group 5 was treated with EA for 14 days. After this period, biochemical and histopathological parameters were evaluated in serum samples and testicular tissue. SA markedly reduced levels of serum testosterone, total antioxidant capacity, reduced glutathione as well as the activity of antioxidant enzymes. Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-1 beta and nitric oxide in testes. Treatment with EA was found to reduce testicular arsenic accumulation and oxidative stress parameters. In addition, EA improved the serum testosterone level, testicular antioxidant markers and histological parameters after exposure to SA. EA may emerge as a promising therapeutic option to protect testes from arsenic-induced toxicity through reducing oxidative stress and inflammatory responses.

Item Type: Article
Keywords: Ellagic acid Arsenic Male infertility Testes Oxidative stress Rat induced oxidative stress nitric-oxide production lipid-peroxidation kappa-b rat-brain testis inflammation mechanisms sperm cyclophosphamide Research & Experimental Medicine Pharmacology & Pharmacy
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Page Range: pp. 1464-1472
Journal or Publication Title: Biomedicine & Pharmacotherapy
Journal Index: ISI
Volume: 103
Identification Number: https://doi.org/10.1016/j.biopha.2018.04.194
ISSN: 0753-3322
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/124

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