Repository of Research and Investigative Information

Repository of Research and Investigative Information

Dezful University of Medical Sciences

Lycopene abrogates di-(2-ethylhexyl) phthalate induced testicular injury by modulating oxidative, endocrine and inflammatory changes in mice

(2018) Lycopene abrogates di-(2-ethylhexyl) phthalate induced testicular injury by modulating oxidative, endocrine and inflammatory changes in mice. Life Sciences. pp. 265-271. ISSN 0024-3205

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Abstract

Di (2-ethylhexyl) phthalate (DEHP) is one of the environmental pollutants that causes testicular damage. Lycopene (LYCO), the main active carotenoid in red fruits and vegetables, has well-known antiinflammatory and antioxidant activities. The present study aimed to investigate the effects of LYCO on DEHP-induced testicular injury in male mice. DEHP (2 g/kg, p.o.) was given for two weeks to mice. LYCO was given at 4 mg/kg, p.o., for two weeks, starting the same day of DEHP insult. Serum testosterone, luteinizing hormone and follicle stimulating hormone and testicular total antioxidant status, malondialdehyde, nitric oxide, glutathione, superoxide dismutase, glutathione peroxidase, catalase, tumor necrosis factor-alpha, interleukin-1 beta were measured. Also, testicular histopathological examination and sperm analysis were evaluated. Results showed that administration of LYCO significantly attenuated the DEHP-induced gonadotoxicity. Also, the gonadoprotective effects of LYCO were confirmed by the histopathological examination of the testes. Our results suggested that LYCO has produced attenuation of inflammatory, oxidative stress and hormonal parameters against DEHP-induced gonadotoxicity.

Item Type: Article
Keywords: Di(2-ethylhexyl) phthalate Lycopene Oxidative stress Inflammation testosterone production reproductive-tract sprague-dawley male-rat toxicity stress cells supplementation antioxidant protects Research & Experimental Medicine Pharmacology & Pharmacy
Subjects: QS Human Anatomy > QS504-532 Histology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Histology and Anatomy
Page Range: pp. 265-271
Journal or Publication Title: Life Sciences
Journal Index: ISI
Volume: 207
Identification Number: https://doi.org/10.1016/j.lfs.2018.06.009
ISSN: 0024-3205
Depositing User: مهندس مهدی شریفی
URI: http://eprints.dums.ac.ir/id/eprint/118

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